The science of multi-peptide formulations -- synergy and antagonism | Skincare University

※ The information in this section is based on Japanese cosmetics regulations (Pharmaceutical and Medical Device Act / 薬機法). Ingredient classifications, permitted concentrations, and labeling requirements may differ in your country or region.

LEVEL 4 Complete Guide to Peptides

Peptide combinations involve synergy and antagonism. Excellent multi-peptide formulations require deep scientific understanding.

Different mechanisms = synergy

Signal + enzyme-inhibiting peptides achieve 1+1>2.

Receptor competition

Same-receptor peptides compete and diminish effects.

3-layer approach

Layer 1 (immediate): Neuropeptides. Layer 2 (medium): Signal. Layer 3 (long-term): Enzyme-inhibiting. Immediate + lasting results.

Vitamin C & Retinol

Vitamin C (low pH) may degrade peptides — use AM/PM separately. Retinol compatible but needs stabilization.

KAIAN develops evidence-based peptide skincare products.
Feel free to reach out with questions.

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