LEVEL 4
Skin Longevity Care
Skin Longevity care is not about "doing something that vaguely seems good" -- it is about targeting specific molecular pathways. Here we explain the five key targets.
Chronic low-grade inflammation -- When NF-kB is activated, inflammatory cytokines such as IL-6 and IL-8 are released, which activate MMP and degrade collagen. This inflammatory cascade accelerates skin aging as "silent inflammation" invisible to the eye. Effective care ingredients include niacinamide, CICA (Centella asiatica extract), and fermented ingredients.
Oxidative stress -- ROS (reactive oxygen species) leakage from mitochondria combined with age-related decline in endogenous antioxidant enzymes leads to accumulated oxidative damage. Key antioxidant defense ingredients include vitamin C, vitamin E, and astaxanthin.
ECM homeostasis -- The goal is to keep the turnover balance of collagen, elastin, and hyaluronic acid in a "synthesis-dominant" state. When degradation exceeds synthesis, skin firmness and elasticity are lost. Signal peptides, retinoids, and vitamin C are effective care ingredients.
Barrier function -- In addition to supplementing ceramides, the primary component of intercellular lipids, supporting the commensal bacterial balance through prebiotics and postbiotics is essential. When barrier function is healthy, chronic inflammation triggered by external stimuli is also suppressed.
Cellular quality control -- When proteostasis (protein quality control mechanisms) decline, abnormal proteins accumulate and cellular function deteriorates. Trehalose and niacinamide are reported to contribute to maintaining these quality control mechanisms.
Simultaneously supporting all five molecular targets is the ideal Skin Longevity care approach. Rather than focusing on just one, a comprehensive approach is essential.
KAIAN develops skincare products based on scientific evidence.
Feel free to ask questions about ingredients and formulations.
