Skincare University

The scientific foundation of personalized skincare

LEVEL 5
What "Suits Your Skin" Means

※ The information in this section is based on Japanese cosmetics regulations (Pharmaceutical and Medical Device Act / 薬機法). Ingredient classifications, permitted concentrations, and labeling requirements may differ in your country or region.
LEVEL 5 What "Suits Your Skin" Means

The ultimate form of "suits your skin" is personalization based on individual biological characteristics. Here we explain three axes of individualization.

Axis 1: Genomics (Genetic Predisposition)

FLG gene mutations are associated with barrier function vulnerability, increasing atopic dermatitis risk 2-3 fold. MC1R mutations determine individual differences in UV sensitivity, and MMP1 promoter polymorphisms are involved in genetic differences in aging rate.

Axis 2: Epigenetics

UV exposure alters DNA methylation patterns, silencing collagen genes. Niacinamide (SIRT1 activation) and retinoids are ingredients that act directly on epigenetics.

Axis 3: Microbiome

Each individual's commensal bacterial composition is unique, like a fingerprint. 16S rRNA analysis can profile each person's unique microbiome.

The 4 Axes of Personalization Genomics Genetic Foundation (FLG, MC1R, MMP1) Epigenetics Current Gene Expression State Microbiome Skin Commensal Ecosystem Real-Time Skin Metrics Current Skin State AI Integrated Analysis Personalized Skincare Protocol Integrating 4 axes to design individually optimized formulations Lower layers are more stable; upper layers fluctuate in real time

Integrated Personalization

Genomics + Epigenetics + Microbiome + Real-time skin measurement. By integrating these through AI analysis, designing formulations and care protocols optimized for each individual becomes possible.

KAIAN develops skincare products based on scientific evidence.
Feel free to ask questions about ingredients and formulations.

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