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Antioxidant

Bakuchiol

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AntioxidantFirmness / AgingSoothing
INCI: Bakuchiol
In short · TL;DR
Category
Antioxidant
Effect
Retinol-like wrinkle improvement and collagen synthesis promotion without irritation. Also called 'next-generation retinol'
Concentration
0.5-2%
Effect
Retinol-like wrinkle improvement and collagen synthesis promotion without irritation. Also called 'next-generation retinol'
Mechanism
Plant-derived (Psoralea corylifolia seed) meroterpene. Partial agonist activity at retinoic acid receptors (RAR). Promotes collagen I/III/IV gene expression. Also possesses antioxidant and anti-inflammatory activity
Typical concentration
0.5-2%
Onset
Wrinkle improvement and pigmentation improvement: 12 weeks
Cautions
Safe for use during pregnancy (no contraindication unlike retinol). Can be used during the day. Additive effect when combined with retinol
Evidence & references
Dhaliwal et al. (2019) 'Prospective randomized double-blind assessment of bakuchiol vs retinol' PubMed (equivalent effect to retinol 0.5%, significantly less irritation)
Journal

Related Journal

2
Aesthetic Medicine vs Home CareRetinol formulations vs prescription tretinoin -- the science of concentration and efficacySkin Longevity SeriesChoosing Skin Longevity: The Pledge KAIAN Makes This July
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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