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Peptides

FGF (Fibroblast Growth Factor)

pdrn-trend-check
MoisturizingFirmness / Aging
In short · TL;DR
Category
Peptides
Effect
Dermal fibroblast proliferation promotion, collagen and elastin synthesis promotion
Concentration
0.0001-0.001%
Effect
Dermal fibroblast proliferation promotion, collagen and elastin synthesis promotion
Mechanism
Fibroblast growth factor. Binds to FGF receptor → Activates dermal fibroblasts → Promotes collagen, elastin, and hyaluronic acid synthesis. While EGF acts on the epidermis, FGF acts on the dermis
Typical concentration
0.0001-0.001%
Onset
Firmness and elasticity improvement: 8-12 weeks
Cautions
Like EGF, large molecular weight limits transdermal absorption. Quality variation issues with topical application of natural growth factors. Chemically synthesized peptides (such as Oligopeptide-24) were designed as alternatives to EGF/FGF for this reason
Evidence & references
Extensive research in regenerative medicine. Large-scale RCTs as cosmetics are limited
Journal

Related Journal

2
The Complete Peptide GuideNext-generation peptides -- synthetic biology and drug delivery frontiersSkin Longevity SeriesIs PDRN (Salmon DNA) the Real Deal? Grading Regenerative Buzz Ingredients with Science
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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