Lysine HCl

We confirmed this ingredient's definition and its registered function in public regulatory databases, but found no published study data on how the ingredient itself acts on the skin (checked by KAIAN, September 2026). We will update this page if new reports appear.

The hydrochloride salt of lysine, a basic amino acid with two amino groups; formulated to condition the skin

In an analysis of free amino acids in human stratum corneum and skin surface film, lysine was reported only as a combined value with ornithine (a 1966 study); the amount of lysine alone and its position within NMF are unconfirmed. Human studies showing an effect of topical application alone were also not confirmed

No public data on typical concentrations in cosmetics could be confirmed (varies by product)

No public data on the time to a perceptible effect with topical use could be confirmed

Ingredient-specific irritation data not confirmed. The US CIR Expert Panel concluded that α-amino acids are safe as cosmetic ingredients under the practices of use and concentration assessed (2013; whether this ingredient was among those assessed is unconfirmed)