Glutathione

AntioxidantFirmness / AgingBrightening

INCI: Glutathione

In short · TL;DR

Category

Antioxidant

Effect

Potent antioxidant, brightening (melanin synthesis pathway control), detoxification

Concentration

0.5-2% (topical)

Effect

Potent antioxidant, brightening (melanin synthesis pathway control), detoxification

Mechanism

A tripeptide composed of three amino acids: glutamic acid, cysteine, and glycine. The major intracellular antioxidant. Brightening effect through tyrosinase inhibition and shifting the synthesis pathway from eumelanin to pheomelanin. Involved in detoxification as a substrate for glutathione S-transferase

Typical concentration

0.5-2% (topical)

Onset

Brightening effect: 8-12 weeks (topical)

Cautions

Limited transdermal absorption efficiency. Stability challenges (easily oxidized)

Evidence & references

Watanabe et al. (2014) "Glutathione as a skin-whitening agent" PubMed

This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.

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