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Palmitoyl Pentapeptide-4 Matrixyl

beauty-research-century
Firmness / Aging
INCI: Palmitoyl Pentapeptide-4
In short · TL;DR
Category
Peptides
Effect
Collagen synthesis promotion, wrinkle improvement
Concentration
Stock solution 2-8%
Effect
Collagen synthesis promotion, wrinkle improvement
Mechanism
The pro-collagen I C-terminal fragment (Pal-KTTKS) acts as a feedback signal for matrix synthesis, promoting collagen production (the active of the original Matrixyl®). Note: often simplified as 'TGF-β pathway activation,' but a TGF-β-specific action is not well established.
Typical concentration
Stock solution 2-8%
Onset
Wrinkle improvement: 8-12 weeks
Cautions
High stability and easy to formulate
Evidence & references
Robinson et al. (2005) Int J Cosmetic Science [PubMed]
Journal

Related Journal

4
The Complete Peptide GuideFour types of peptides -- signal, neuro, carrier, and enzyme-inhibitingThe Complete Peptide GuidePeptide effective concentrations and the penetration challengeSkin Longevity SeriesThe Three Dermal Pillars — Collagen, Elastin and Hyaluronic AcidSkin Longevity SeriesA Century of Beauty Research
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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