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Antioxidant
Spermidine
longevity-pledge-2026
Antioxidant
INCI: Spermidine HCl
Under source verification
This page is under source verification. The figures and timeframes shown are provisional and are not confirmed recommendations.
In short · TL;DR
Category
Antioxidant
Effect
Autophagy inducer, mitochondrial biogenesis, longevity signaling
Concentration
0.01-0.1%
Effect
Autophagy inducer, mitochondrial biogenesis, longevity signaling
Mechanism
eIF5A activation → autophagy gene expression → clearance of aged cellular proteins
Typical concentration
0.01-0.1%
Onset
8-12 weeks for wrinkle/sagging trend
Cautions
Heat sensitive
Evidence & references
Nat. Med. 2016: longevity extension, human cohort
Journal
Related Journal
1This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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