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Moisturizing & Barrier

Trehalose

moisture-layer-design
BarrierMoisturizing
INCI: Trehalose
In short · TL;DR
Category
Moisturizing & Barrier
Effect
Moisturizing, cell protection, autophagy induction (evidence from non-skin models)
Concentration
1-5%
Effect
Moisturizing, cell protection, autophagy induction (evidence from non-skin models)
Mechanism
A disaccharide composed of two glucose molecules. Stabilizes cell membranes and protects against desiccation and heat stress. Induces autophagy independently of mTOR (reported in neuronal/disease models; effect in topical skin application not established)
Typical concentration
1-5%
Onset
Moisturizing: immediate. Autophagy promotion: with continued use
Cautions
Extremely high safety
Evidence & references
Sarkar et al. (2007) Nature Chemical Biology. A key component of desiccation tolerance in resurrection plants (Selaginella)
Journal

Related Journal

3
Anti-Aging vs LongevityMolecular strategy for Skin Longevity—telomeres, NAD+, and autophagySkin Longevity CareMolecular targets of Longevity care—understanding what you’re caring forSkin Longevity SeriesDesigning Moisture in Layers — Humectant, Occlusive, Emollient
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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